Effects of Dietary Fat Restriction on Endurance Training-induced Metabolic Adaptations in Rat Skeletal Muscle

Endurance exercise training enhances muscle fat oxidation while concomitantly reducing carbohydrate (glycogen) utilization during exercise, thereby delaying the onset of fatigue. This study examined effects dietary restriction on endurance training-induced metabolic adaptations in rat skeletal muscle. Male Sprague-Dawley rats were placed either a control diet (CON: 19.2% protein, 21.6% fat, and 59.2% as percentage total energy) or fat-restricted (FR: 21.5% 2.4% 76.1% for 4 wks. Half each group performed daily 6-h swimming (two 3-h sessions separated by 45 min rest) 5 days wk. significantly increased expression β-hydroxyacyl CoA dehydrogenase (βHAD), key enzyme oxidation, pyruvate kinase (PDK4), an inhibitory regulator glycolytic flux, fed CON diet. However, such increases βHAD PDK4 partially suppressed FR diet, suggesting that may diminish enhancement reduction glycogen exercise. We then assessed rate acute bout trained consequently found had higher compared with In conclusion, attenuate